Frequently Asked Questions

What is ProUCRO®?

IBD is a challenging disease with over 1 million people in the United States with the diagnosis, over 30,000 new cases annually, and over 2 million ambulatory care visits yearly. (18) There is compelling data within the literature pointing to micronutrient deficiencies in the setting of IBD. Although any vitamin or mineral may become deficient in IBD patients, Vitamin D, calcium, iron, vitamin B12, folate, zinc, selenium and magnesium are the most common and may have significant clinical consequences.

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References

1.) Siffledeen JS, Siminoski K, Steinhart H, et al. The frequency of vitamin D deficiency in adults with Crohn’s disease. Can J Gastroenterol. 2003;17:473-478.
2.) Tajika M, Matsuura A, Nakamura T, et al. Risk factors for vitamin D deficiency in patients with Crohn’s disease. J Gastroenterol.2004;39:527-533.
3.) Massironi S, Rossi RE, Cavalcoli FA, et al. Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches. Clin Nutr 2013;32:904-910
4.) Vagianoski K, Bector S, McConnel J, et al. Nutrition assessment of patients with inflammatory bowel disease. J Parent Ent Nutr 2007;31:185-191
5.) Schreiber S, Wedel S. Diagnosis and treatment of anemia in inflammatory bowel disease. Inflamm Bowel Dis 1997;3:204 –216
6.) Horina JH, Petritsch W, Schmid CR, et al. Treatment of anemia in inflammatory bowel disease with recombinant human erythropoietin: results in three patients. Gastroenterology 1993;104:1828 –1831
7.) Thomson ABR, Brust R, Ali MAM, et al. Iron deficiency anemia in inflammatory bowel disease, Am J Dig Dis 1978;23:705-709
8.) Gomollón F, Gisbert JP. Anemia and inflammatory bowel diseases. World J Gastroenterol 2009;15:4659-4665.
9.) Yakut M, Ustün Y, Kabaçam G, et al. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur J Intern Med 2010;21:320-323
10.) Goh J, O’Morain A. Review article: nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther 2003;7:307-320
11.) Hinks LJ, Inwards KD, Lloyd B, et al. Reduced concentrations of selenium in mild Crohn’s disease. J Clin Pathol1988;41:198-201
12.) Ojuawo A, Keith l. Serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Centr Afr J Med 2002;48:116-119
13.)Galland L. Magnesium and inflammatory bowel disease. Magnesium 1988;7:78-83
14.) Nylin H, Dyckner T, Ek B, et al. Magnesium in Crohn’s disease. Acta Med Scan Suppl 1982;661:21-25.
15.) Hessov I, Hasselblad C, Fasth S, et al. Magnesium deficiency after ileal resection for Crohn’s disease. Scan J Gastroenterol 1983;18:643-649
16.) Galland L. Magnesium and inflammatory bowel disease. Magnesium 1988;7:78-83
17.) Andersson H, Bosaeus I, Brummer R-J, et al. Nutritional and metabolic consequences of extensive bowel resection. Dig Dis 1986;4:193–202
18.) Weisshof R, Chermesh I. Micronutrient deficiencies in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 20;18:576–581